@article{The Active Ingredients Of Green Betel Leaves (Piper Betle L.) and Their Uses in the Health Sector_2025, volume={12}, url={https://jimki.bapin.or.id/main/article/view/937}, DOI={10.53366/jimki.v12i2.937}, abstractNote={
Abstract Introduction: Green betel leaf (Piper betle L.) is a traditional medicinal plant widely used in Southeast Asia, including Indonesia, and contains various bioactive compounds with potential for phytopharmaceutical development. Method: This study employed a bibliometric-based scoping review approach, where bibliographic data related to Piper betle L were retrieved from the Scopus database and analyzed using R-Biblioshiny to map publication trends, author collaborations, and relevant research themes. Discussion: In vitro research results demonstrate broad antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as anti-inflammatory and antioxidant properties that support wound healing. Formulation innovations, such as betel extract-based nanoemulsions, have been shown to increase the solubility, stability, and effectiveness of bioactive compounds, making them effective for oral health applications, particularly as a natural mouthwash for caries prevention. Comparisons across national and international studies demonstrate the consistent benefits of green betel leaf as a therapeutic agent, although further research in the form of large-scale clinical trials is still needed. Conclusion: Thus, green betel leaf can be seen as a potential source to support the innovation of safe, effective, and standardized herbal-based health products. Keywords: Active Ingredients; Piper betle L.; Green Betel Leaf; Health Implementation
}, number={2}, journal={JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia}, year={2025}, month={Dec.}, pages={290–305} }